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KMID : 0607520220300020165
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Korean Journal of Psychosomatic Medicine
2022 Volume.30 No. 2 p.165 ~ p.171
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The Effect of Second-Generation Antipsychotics Administration for 1-Year on the Platelet Activities in Patients With Schizophrenia: Retrospective Study
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Oh Yoon-Seok
Lee Jong-Wook
Oh Hong-Seok
Kim Seung-Jun
Lee Na-Hyun
Im Woo-Young
Kim Ji-Woong
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Abstract
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Objectives：This study was conducted to investigate the effect of 1-year administration of second-generation antipsychotics (SGAs) on the platelet activity in patients with schizophrenia through a retrospective review of the medical records.
Methods：The mean platelet component (MPC) value was used as an index of the platelet activity. The included subjects (N=24) were the patients who were confirmed to have taken SGAs continuously for one year after the first MPC measurement had been performed. The change of MPC was verified through a paired sample t-test.
Results：The result revealed that the mean MPC value was significantly decreased from 26.5±1.4 g/dL to 25.6± 1.8 g/dL after 1-year administration of SGAs from the time of the first MPC measurement.
Conclusions：This study suggests that 1-year administration of SGAs may be related with increased platelet activity, and
that close monitoring for risks such as cerebrovascular/ or thromboembolic diseases may be necessary during SGAs treatment in clinical practice.
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KEYWORD
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Second-generation antipsychotics, Mean platelet component, Platelet activity, Schizophrenia, Cerebrovascular/cardiovascular diseases
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